Analytical study of an exclusive genetic switch

Analysis of genetic toggle switch systems encoded on plasmids.

Genetic switch systems with mutual repression of two transcription factors, encoded on plasmids, are studied using stochastic methods. The plasmid copy number is found to strongly affect the behavior of these systems. More specifically, the average time between spontaneous switching events quickly increases with the number of plasmids. It was shown before that for a single copy encoded on the c...

Factors associated with exclusive breastfeeding among primiparous women

Introduction: Exclusive breastfeeding (EBF) is infant’s breast milk consumption without supplementation of any kind of food or drink. Nowadays, EBF has been considered as a key strategy for ensuring the growth and survival of the child. This study aims to investigate the factors affecting exclusive breastfeeding in primiparous women referring to Tehran health centers. Methods: In this analytica...

Editorial: Could Speciation Across Evolution be Governed by Genetic Switch Codes at Short Tandem Repeats?

Determinants of Exclusive Breastfeeding Practices in Kandahar, Afghanistan: A Cross-Sectional Analytical Study

Background It is recommended for mothers to start breastfeeding their infants within the first hour after birth and exclusively breastfeed them for the first 6 months of their life. Exclusive breastfeeding (EBF) has both short- and long-term benefits for both mother and infant. Main objective of this study was to establish the determinant...

Chemical models of genetic toggle switches.

We study by mean-field analysis and stochastic simulations chemical models for genetic toggle switches formed from pairs of genes that mutually repress each other. To determine the stability of the genetic switches, we make a connection with reactive flux theory and transition state theory. The switch stability is characterized by a well-defined lifetime tau. We find that tau grows exponentiall...